Kir6.2 1 31 (MLSRKGIIPEEYVLTRLAEDPAKPRYRARQR) Removed by authors --------------------------------------------------- 32 46 47 54 RARFVSKKGNCN VAHKNIRE QGRFLQDVFTTLVDLKWPHTLLIFTMSFL N domain loop CSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQV TIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAE TLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGE VVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQ DLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVD YSKFGNTIKVPTPLCTARQLDEDRSLLDA ------------------------------------------------------- (LTLASARGPLRKRSVPMAKAKPKFSISPDSLS)Removed by authors. ....,....1....,....2....,....3....,....4....,....5....,....6....,....7....,....8....,....9....,....10.1.,....11.1.,....12.1.,....13.1.,....14.1.,....15.1.,....16.1.,....17.1.,....18.1.,....19.1.,....20.1.,....21.1.,....22.1.,....23.1.,....24.1.,....25.1.,....26.1.,....27.1.,....28.1.,....29.1.,....30.1.,....31.1.,....32.1.,....33.1.,....34.1.,....35.1.,....36.1.,....37.1.,....38.1.,....3 AA MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLDALTLASARGPLRKRSVPMAKAKPKFSISPDSLS | Removed by authors || N domain || loop || TM domain ||L| C domain | Removed by authors | 1-31 32-46 47-54 55-172 173-176 177-358 Energy Based on KirBac Based on Kir3.1 Minimization Based on Kir3.1 Based on Kir3.1 OBS_sec PROF_sec HHHHHHH EEE EEEEEE HHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EEEEEEEEEEEEEE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EEE EEEEE EEEEEEEE EEEEEEEEEEEE EEEEEEEEEEE EEEEE EEEEEEE HHHHH EEEEEEEEE HHHHH EE EEE EEEEE HHHHHH HHH Rel_sec 955434565275453301577775411011233123306832355310102124578889887510002566788898888888888888777542121366656655421200100001223333444430033345654725677777887765677666776777652001210021011120467621672577754203452210222332222210247775233333333110024677632664030566642565642246734520257604788874011112310011111241100002410000212666156521102331125576335233421010210267777767523144630125664231545469 SUB_sec LLL...LLL.HH.H....LLLLLL..............LL...EE.........HHHHHHHHHH.....HHHHHHHHHHHHHHHHHHHHHHHHH......LLLLLLLL.............................LLL.L.HHHHHHHHHHHHHHHHHHHHHHHHHHH.................EEE..LL.EEEEE.....L..................LLLL...............LLLL..EE....EEEE..LLLL....LL..H...LLL..EEEEE..................................LLL.EEE..........LLLL..L.............LLLLLLLLL.....L....LLL....L.L.LL O_3_acc bbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbb P_3_acc e e e bb ee bbe beeeeeeee e ee b ee eb bbb beeb ebb bbbbbbeb bbbbbbbbbbbbbbbbbbbbbbbbbbbbb e eeee e eeb bbbbbbbbbbbbbbbbbbbbb eeb bbbbbbbbbbbbbbbbbbbbbbbbbb bbe e eeb bb bbbbbb b bbbbbbbb eebbbbb b b bb eeeeee e beb ebebe e ee bbbbbbbbbbbbbb ebbbbe b e b eeeeb bbbbb bbbbbbb bb bb bbbb bbbbbb bb bb eeeeb b be b e e bbe beee eebee e eeeeee e e be e eb e ee Rel_acc 310110103112312311311412221000111202102021240212021013173278016220102247878997899679979997677331023300131100101212002226827561636687431100111220226679946987688496767465222331021122421020346332002226560511012002313131322122010340111112202120111011124674322373324101101121024231203433989890311000110114101111005322022012312331423320022121131000101142214112223212013220012110110100112110001025 SUB_acc .....................e.....................b...........b..bb..b.......bbbbbbbbbbbbbbbbbbbbbbb..........................bb.bbb.b.bbbbb.............bbbbbbbbbbbbbbbbbbbbbb............b......bb........bbb.b........................e.....................bbbb....b...b...........e......e..bbbbb............b........b...............e.....................e...e......................................e